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M9480015.TXT
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1994-08-09
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Document 0015
DOCN M9480015
TI American cutaneous leishmaniasis: in situ characterization of the
cellular immune response with time.
DT 9410
AU Lima HC; Vasconcelos AW; David JR; Lerner EA; Nucleo de Medicina
Tropical, Universidade Federal do Ceara,; Fortalez, Brazil.
SO Am J Trop Med Hyg. 1994 Jun;50(6):743-7. Unique Identifier : AIDSLINE
MED/94295850
AB The cellular nature of the infiltrate in the skin of patients with
American cutaneous leishmaniasis was characterized by
immunohistochemistry. The study population consisted of patients in
Ceara, Brazil, an area where Leishmania braziliensis is endemic.
Biopsies were taken from lesions present for 0.5-4 months duration and
sections were stained with antibodies to T cells, T cell subsets, B
cells, and macrophage markers to quantitate these cell types. The T
cells accounted for 37.0 +/- 7.6% (mean +/- SD) of the infiltrate. The
average percentages of CD4- and CD8-positive T cells were similar to
each other, 20.4 +/- 9.0% and 19.9 +/- 6.7%, respectively. Interleukin-2
receptor-positive cells and B cells were infrequent, 3.7 +/- 3.0% and
2.3 +/- 3.1%, respectively. When the relationship between the age of the
lesion at biopsy and the cellular phenotype was examined, it was noted
that the percentage of positive cells remained fixed for all cell types
except for that of gamma delta cells, which decreased with time. It is
likely that gamma delta T cells are important in the early phase of the
immune response to L. braziliensis and may, in general, be important in
the early immune response of granulomatous diseases.
DE Adolescence Adult Animal Antibodies, Monoclonal/IMMUNOLOGY Biopsy
Child Child, Preschool CD4-CD8 Ratio Female Human Immunity,
Cellular Immunoenzyme Techniques Immunophenotyping Infant Leishmania
braziliensis/*IMMUNOLOGY/ISOLATION & PURIF Leishmaniasis,
Cutaneous/*IMMUNOLOGY Male Middle Age
Skin/*IMMUNOLOGY/PATHOLOGY/PARASITOLOGY Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).